The Arthritis Remedy Few Doctors Talk About: Why DMSO Is Making a Comeback

If you struggle with stiff joints, aching knees, or swollen fingers, you already know how frustrating arthritis can be.

For many people, the usual options—pain relievers, anti-inflammatory drugs, or injections—offer only temporary relief. And in many cases they come with unwanted side effects.

But there is another option that has quietly circulated for decades among integrative physicians and alternative practitioners: DMSO (dimethyl sulfoxide). 

>> See my article DMSO: The Remedy That Medicine Tried to Bury 

Although it rarely receives mainstream attention, DMSO has been studied extensively for its remarkable ability to reduce inflammation, relieve pain, and penetrate deeply into tissues. In fact, its unique properties make it unlike almost anything else used for joint health today.

For those dealing with arthritis, it may offer a surprisingly simple way to support comfort, mobility, and healing. 

A Forgotten Arthritis Study From the 1960s

Long before many of today’s arthritis drugs existed, researchers were already exploring the therapeutic potential of DMSO. In the early 1960s, physicians led by Oregon researcher Dr. Stanley W. Jacob, one of the pioneers of DMSO research, began studying its effects on joint pain and inflammation.

In one of the early double-blind clinical investigations, arthritis patients applied a topical DMSO solution to painful joints while others received a placebo. The results were striking for the time. Many participants using DMSO reported reduced pain, improved mobility, and less swelling in affected joints after several weeks of regular application.

The findings suggested that DMSO possessed both anti-inflammatory and analgesic properties, prompting scientists to investigate how it might influence joint tissues, circulation, and oxidative stress.

Although interest in DMSO slowed in later decades due to regulatory concerns, these early studies helped establish the foundation for the growing curiosity surrounding this unusual compound. Today, as more practitioners revisit therapies that support the body’s natural healing processes, DMSO is once again being explored for its potential role in easing joint discomfort and supporting mobility. 

Why DMSO Is So Different

DMSO is not just another topical remedy.

What makes it extraordinary is that it acts as both:

• a powerful anti-inflammatory compound
•  a cellular transport molecule

That means it can help calm inflammation while also carrying beneficial compounds directly through the skin and into deeper tissues. For conditions involving inflamed joints, connective tissue, and cartilage breakdown, this combination is especially intriguing.

1. Calming the Fire of Joint Inflammation

Whether someone has osteoarthritis or rheumatoid arthritis, inflammation inside the joint capsule is one of the main drivers of pain and stiffness.

Research and clinical use suggest that DMSO may help:

• reduce inflammatory signaling
• decrease swelling in surrounding tissue
• improve circulation in injured joints

When applied to areas such as the knees, hands, or shoulders, many individuals report a gentle warming sensation followed by a noticeable reduction in stiffness and discomfort.

Early clinical observations have suggested that regular use may help reduce joint inflammation within days or weeks.

2. Natural Pain Relief Without Harsh Drugs

Another reason DMSO has attracted so much attention is its ability to act as a free-radical scavenger.

Arthritic joints tend to contain high levels of:

• oxidative stress
• inflammatory cytokines
• damaged cartilage cells

By neutralizing oxidative damage in inflamed tissue, DMSO may help calm the biochemical processes that amplify pain.

For some people, this translates into relief from:

• knee arthritis
• hand arthritis
• shoulder pain
• hip discomfort

without relying as heavily on conventional anti-inflammatory drugs.

3. A Unique Ability to Deliver Healing Compounds

As previously mentioned, one of the most fascinating characteristics of DMSO is its ability to transport other substances through the skin and into deeper tissues.

This has led many practitioners to combine it with other supportive compounds for joint health, including:

• magnesium, which helps relax muscles and joints
• MSM (methylsulfonylmethane), a sulfur compound that supports connective tissue
• castor oil, traditionally used for inflammation
• herbal extracts such as arnica or comfrey

Because DMSO penetrates the skin so effectively, these substances may reach tissues that typical topical creams never access.

4. Protecting Cartilage From Further Damage

In osteoarthritis, cartilage gradually breaks down. When this protective cushion deteriorates:

• bones begin rubbing together
• inflammation increases
• mobility declines

Some laboratory research suggests that DMSO may help protect chondrocytes, the specialized cells responsible for maintaining cartilage.

By reducing oxidative stress and inflammation, DMSO may help slow some of the degenerative processes that occur inside aging or damaged joints.

5. Supporting Mobility and Everyday Movement

Perhaps the most meaningful benefit reported by many users is improved movement.

People dealing with arthritis often describe improvements in:

• morning stiffness
• joint flexibility
• range of motion
• walking or gripping ability

These improvements likely reflect several mechanisms working together—reduced inflammation, improved circulation, and decreased oxidative stress within the joint.

A Few Important Safety Guidelines

Because DMSO penetrates the skin so easily, it must be used carefully.

Anything present on the skin can potentially be carried into the bloodstream along with it.

For that reason:

• use only high-purity pharmaceutical or medical-grade DMSO
• make sure skin is clean and free of lotions, perfumes, or chemicals before applying
• many practitioners recommend starting with lower concentrations around fifty to seventy percent

For individuals dealing with arthritis, it represents a fascinating reminder that some of the most promising tools in health are not always the newest ones. Sometimes they are simply the ones that were overlooked.

Where can you find DMSO?

I like these:

Resources include:

Capriotti K, Capriotti JA. Dimethyl sulfoxide: history, chemistry, and clinical utility in dermatology. J Clin Aesthet Dermatol. 2012 Sep;5(9):24-6. PMID: 23050031; PMCID: PMC3460663. 

Stanley W. Jacob, Interview with Dr. Stanley Jacob (Portland: Oregon Health & Science University Digital Collections, 1998), https://digitalcollections.ohsu.edu/record/3229?ln=en 

Elisia I, Nakamura H, Lam V, Hofs E, Cederberg R, Cait J, Hughes MR, Lee L, Jia W, Adomat HH, Guns ES, McNagny KM, Samudio I, Krystal G. DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis. PLoS One. 2016 Mar 31;11(3):e0152538. doi: 10.1371/journal.pone.0152538. PMID: 27031833; PMCID: PMC4816398. 

Anzelc M, Burkhart CG. DMSO: an aid to combat pain and pruritus. Dermatol Online J. 2021 Nov 15;27(11). doi: 10.5070/D3271156086. PMID: 35130398.