What Your Doctor May Be Missing About The Female Heart

Heart disease has long been thought of as a “man’s disease,” but did you know that it’s actually the #1 killer of women?

The reality is, women’s hearts are different, and what works for men may not always work for women when it comes to prevention, diagnosis, and treatment. Unfortunately, many women don’t get the right tests—or even the right information—until it’s too late.

The Female Heart: Built Differently

A woman’s heart is typically smaller than a man’s, and so are her arteries. This means that her heart pumps faster but expels less blood per beat, making it more vulnerable to certain stressors. Her hormones—especially estrogen—play a protective role, keeping blood vessels flexible and helping to regulate cholesterol. But as estrogen levels decline with age, that protection fades, increasing the risk of high blood pressure, plaque buildup, and inflammation.

The Silent Signs of a Heart Attack in Women

For decades, heart attack symptoms have been based on male models, but women often experience very different warning signs. Instead of the classic crushing chest pain, women may have:

• Extreme fatigue—feeling “off” or unusually exhausted
• Shortness of breath—even without exertion
• Indigestion or nausea—often mistaken for a stomach issue
• Pain in the neck, jaw, or back—especially between the shoulder blades
• Cold sweats and dizziness—without chest pain

Many women dismiss these symptoms or doctors misdiagnose them as anxiety, reflux, or even menopause-related issues.

What Your Doctor May Be Missing

Did you know that studies show nearly 75 percent of patients hospitalized for a heart attack did not have high cholesterol? And did you know that half of all people with high cholesterol do not have heart disease?

Statistics like these really bust the cholesterol myth and show why statin drugs are not a miracle cure for heart disease. Does this mean we should ignore cholesterol? No, but it does mean we need to understand it better and how it relates to inflammation in the body and heart disease, in particular. See my article: “Super Heart Health Today” for the scoop on this.

Women need a more in-depth look at heart health, and here are some tests that should be on your radar:

• High-Sensitivity C-Reactive Protein (hs-CRP): The #1 test I look at for inflammation specific to the cardiovascular system is the cardio-CRP (C-Reactive Protein), also known as the hs-CRP, which I’ve written about before. More than 30 studies have shown a direct correlation between elevated hs-CRP and heart attack. While the lab’s normal range is usually 0-3mg/dL, the optimal range is less than 1.0 mg/dL for women and less than 0.55 mg/dL for men. When hs-CRP is elevated, I like to boost nitric oxide levels to reduce this inflammation. Citrulline and arginine are two amino acids that are known to increase nitric oxide production and can be easily supplemented*. In addition, I recommend UNI KEY Health’s Daily Greens Formula as a good oxygenating, anti-inflammatory greens formula for daily use.*You will find Citrulline and arginine on my online Fullscript catalog. I recommend L-Citrulline by Jarrow Formulas and L-arginine by Pure Encapsulations. Take as directed by manufacturer.
• Homocysteine: Elevated homocysteine by itself has been shown in studies to be a risk factor for early heart disease. You may feel weak, fatigued, and dizzy when levels are high, and have renal disease. Your blood tests may show that you are low in vitamins B6, B12, and folate. High homocysteine is one of the few health issues treated exclusively by supplementing with vitamins. Because it is most commonly caused by the MTHFR gene mutations, supplementing with the methylated forms of vitamins B6, B12, and folate are the fix for this risk factor. UNI KEY Health’s iron-free Advanced Daily Multivitamins have what you need to restore healthy levels and lower homocysteine.
• Ferritin Levels: High iron stores can be deadly for women post-menopause. An inexpensive ferritin test can indicate whether or not you are at risk. Learn more about this often-overlooked cause of heart disease in my article, “Iron: The Double-Edged Mineral”.For those testing above 150 ng/mL, you’ll want to consider reducing iron intake by cutting out red meat and monitoring supplemental iron intake especially in vitamins and fortified cereals. Cut down on vitamin C and red wine during meals, which are both helpful in the absorption of iron. Surprisingly, there are very few iron-free multivitamins on the market. This is the very reason that I made sure that UNI KEY developed iron-free options. And last, but not least, make it a practice to donate blood regularly. Learn more about this solution in my biohack, “Drain Away Danger: Harnessing Blood Donation to Combat Iron Overload.”

>>For a complete list of tests I recommend, see: “My Top 10 Tests for Heart Disease”.

>>For a wakeup call, check out my podcast interview, “The Great Cholesterol Myth” with highly respected cardiologist, Dr. Stephen Sinatra.

Heart-Smart Strategies for Women

Protecting your heart isn’t just about eating right and exercising—although those are important fundamentals. Women need specific strategies tailored to their unique physiology. Here’s what every woman needs to know:

• Make Magnesium a Priority: Without a doubt, magnesium is the heart’s most critical mineral! In fact, it has been scientifically confirmed that it is the heart’s #1 mineral of all. Magnesium deficiency is a hidden culprit in high blood pressure, irregular heartbeats, and even sudden cardiac arrest. For optimal heart protection, I recommend a dose of 5 mgs of magnesium per 1 pound of body weight per day. My go-to formula is Mag-Key, a full-spectrum blend featuring four unique forms—Glycinate for stress relief, Malate for muscle comfort, Taurinate for heart health, and Orotate for energy and endurance—all enhanced with vitamin B-6 for superior absorption.
• Balance Your Hormones: Low progesterone and estrogen dominance can contribute to heart risks. Bioidentical hormones, liver support, and healthy fats can help keep hormones in check. A simple Salivary Hormone Test takes out all the guesswork and can help identify imbalances so you can take the right steps. Call the team at UNI KEY Health at 800-888-4353 with any questions about ordering and performing this easy at-home test.
• Manage Stress & Sleep: If you are suffering from insomnia, anxiety, fatigue, high blood pressure, heart arrhythmias, muscle cramps or spasms, then you may be missing what’s been called the “master mineral” – magnesium. Involved in more than 350 of the body’s critical functions, magnesium helps with sleep, stress relief, energy production, muscle relaxation, bone health, blood sugar balance, blood pressure, and so much more. It’s estimated that more than 80 percent of Americans are deficient in magnesium, primarily because of stressful lifestyles and high carb diets – it takes 54 molecules of magnesium to process just one molecule of sugar. When choosing a magnesium supplement, it’s important to choose a highly absorbable form, which is why I only recommend Mag-Key from UNI KEY Health. Just 5 milligrams per pound of body weight per day (500 milligrams for 100 pounds, for example) is a good start.

The Bottom Line

Women’s hearts are different from men’s, and it’s time the medical world catches up. Don’t wait for a wake-up call—get the right tests, advocate for yourself, and take charge of your heart health today.

What are you doing to support your heart? Let’s talk in the comments below!

Resources:

National Heart, Lung, and Blood Institute. Women and Coronary Heart Disease. U.S. Department of Health and Human Services, https://www.nhlbi.nih.gov/health/coronary-heart-disease/women.

Houston M. The role of magnesium in hypertension and cardiovascular disease. J Clin Hypertens (Greenwich). 2011 Nov;13(11):843-7. doi: 10.1111/j.1751-7176.2011.00538.x. Epub 2011 Sep 26. PMID: 22051430; PMCID: PMC8108907.

Levine GN. Psychological Stress and Heart Disease: Fact or Folklore? Am J Med. 2022 Jun;135(6):688-696. doi: 10.1016/j.amjmed.2022.01.053. Epub 2022 Mar 9. PMID: 35278355.

Osuna PM, Udovcic M, Sharma MD. Hyperthyroidism and the Heart. Methodist Debakey Cardiovasc J. 2017 Apr-Jun;13(2):60-63. doi: 10.14797/mdcj-13-2-60. PMID: 28740583; PMCID: PMC5512680.