Grapefruit: A Radical New Twist on Weight Loss

October 17, 2018
Ann Louise Gittleman, PhD, CNS

Ann Louise Gittleman, PhD, CNS

Award-winning nutritionist and New York Times bestselling author.

Get ready for the next generation of this tried and true citrus slimmer!

Firstly, women have been using grapefruit diets to slim their stomach and take inches off their waist for years. But what’s going on behind the scenes is even more exciting for your health than what you see in the mirror – and my new Radical Metabolism plan optimizes grapefruit’s fat-burning potential as the next generation of the grapefruit diet!

Grapefruit is the Slimming Citrus Wonder

That being said, researchers at the University of Western Ontario were studying the anti-cancer properties of grapefruit when they came across a startling discovery – human liver cells dump their fat stores when exposed to narigenin, a flavonoid found in grapefruit. Research has found narigenin turns off the genes responsible for making new fat while turning on the genes that use stored fat for energy. Grapefruit’s slimming effects ignites your fat-burning engines, slims your waist and balances your blood sugar.

Grapefruit Targets Belly Fat

Similarly, cortisol plays a key role in the accumulation of belly fat. The narigenin in grapefruit blocks an enzyme in fat tissue and keeps cortisone from converting into cortisol. Not only that, but narigenin blocks glucose production in the liver and helps regulate blood sugar levels, while preventing DNA damage. So as cortisol levels drop and blood sugars normalize, belly fat melts off!

Also, this is good news for those with metabolic syndrome. The weight loss effects combined with reduction in insulin resistance and better lipid profiles were strong enough in studies to classify grapefruit as a weight loss drug!

How to Use Grapefruit for Your Best Weight Loss Success

So, as tempting as it is to find a grapefruit pill to use as a quick fix, it doesn’t produce the same results as eating the whole fruit. All parts of the grapefruit work together to produce tremendous weight loss effects, and can’t be distilled down into a pill. You need the soluble fiber, Vitamin C, and variety of flavonoids to experience the best weight loss results. Studies show that grapefruit is most effective when eaten either before or as a part of every meal, and grapefruit juice should only be substituted during the first meal of the day.

Done the right way, with the whole fruit, you can expect 5 times more weight loss than someone who isn’t consuming grapefruit with every meal. That’s impressive!

Radical Metabolism – The Next Generation Grapefruit Diet

In contrast, past grapefruit diets have drastically limited calories. Often to as little as 800 calories per day, while my new Radical Metabolism plan doesn’t even count calories. If you make grapefruit part of every meal, it will naturally cut your calorie intake and shift your body into a fat-burning state all on its own. Even inhaling its scent will stimulate nerve responses in your GI tract to reduce appetite, then activate nerves within your fat tissue to stimulate fat breakdown.

From the very first juice on the 4 Day Radical Intensive Cleanse to the last salmon dinner served with grapefruit slaw on the 21 Day Radical Reboot, Radical Metabolism is packed full of delicious ways to have your grapefruit with every meal. And I’ll let you in on a secret that only my Radical Metabolizers know – when it comes to grapefruit, bitter is always better for weight loss.

Grapefruit: The Bitter Secret to Better Weight Loss

Most noteworthy, the second Radical Rule you’ll learn through Radical Metabolism is that bitter foods make better bile. Let me explain why this is so important. Bile is made in the liver to break down the fats you eat and bind toxins to escort them out of the body. Without bile, you can’t digest or absorb fat-soluble nutrients like vitamins A, D, E, and K. Those are all important fat-burning essential fats like Omega 3 and Omega 6.

Above all, these fat-soluble nutrients and essential fats are crucial for brain health, hormone production, immunity, energy, cardiovascular health, and every cell membrane in your body. Bile also plays a key role in your thyroid health.

In addition to this, gallbladder disease and obesity are occurring at epidemic rates, and it turns out the two are connected – through bile. If you have thick, sludgy bile it stops flowing freely into the small intestine and stagnates in the gallbladder. It’s not long before gallstones and inflammation develop, and you can’t properly break down fats anymore. These fats are then absorbed into the bloodstream in an unusable form and your body has no choice but to store them.

Remember – bitter foods make better bile. So by incorporating grapefruit into your daily diet, you not only make better quality bile that flows freely, but you rev-up your fat-burning metabolism. Your gallbladder and liver will thank you for it!

My Free Gift to You: 2 Radical Recipes to Jump Start Your Fat-Burning Metabolism

Even more, I’m so confident you’ll love my new Radical Metabolism plan and the results you’ll get, that I’m giving you two delicious grapefruit recipes from the book as a sneak peek!

AM Rise and Shine Juice
Serves: 8 ounces
An energizing way to start your day!
  • 1/2 grapefruit, peeled and seeded
  • 1 carrot
  • 1 cucumber
  • 1/4 head Bibb or Romaine lettuce
  • 1 large handful of fresh mint leaves and stems
  • 1 inch piece of fresh ginger
  • 2 inch piece of fresh turmeric, or 1 teaspoon powdered
  • 1/2 lemon with peel
  1. Clean the fruits and vegetables.
  2. Process all the ingredients (except powdered turmeric) through a juicer. Stir powdered turmeric in, if using.
  3. Drink immediately for maximum nutritional benefits.


Grapefruit Slaw
Serves: 4 servings
This tangy slaw is a great accompaniment to chicken and fish.
  • 3 cups thinly sliced Napa cabbage
  • 2 pink grapefruit, peeled and segmented, 1 tablespoon of juice reserved
  • 1 celery stalk, thinly sliced on the diagonal (approx. 1/2 cup)
  • 1/4 cup coarsely grated carrot
  • 1/4 cup diced red radish
  • 1 1/2 tablespoons umeboshi plum vinegar
  • 1/2 teaspoon finely grated lime zest
  • 1 1/2 teaspoons freshly squeezed lime juice
  • 2 tablespoons toasted pumpkin seeds
  • 1 tablespoon coarsely chopped flat leaf parsley
  • sea salt to taste
  1. Mix together the cabbage, grapefruit, celery, carrot, and radish in a medium-sized bowl.
  2. Whisk together the reserved grapefruit juice, plum vinegar, lime zest, and lime juice in a small bowl.
  3. Toss the slaw with the dressing. Sprinkle with the pumpkin seeds, parsley, and salt to taste.


Finally, are you ready to go from fat, fatigued, and an “over 40” metabolism to energized and slim? Then don’t wait – order your copy of Radical Metabolism now and join thousands of other ladies and gentlemen in my Radical Metabolism Revolution Facebook Group!

Related Articles and Podcasts

Ann Louise Gittleman, PhD, CNS, is an award-winning New York Times bestselling author of more than thirty books including The Fat Flush Plan series and her latest book, Radical Metabolism. She’s been rewriting the rules of nutrition for more than 40 years and is internationally recognized as a pioneer in the field of diet, detox and women’s health issues. 

For a FREE daily dose of tips and strategies for maintaining healthy weight, conquering insomnia, and much more…check out my Radical Health Tips.

I’d like to meet and greet you on my Facebook groups, so won’t you check us out at the Radical Metabolism RevolutionFat Flush Nation, or my Inner Circle!


  1. Marijke

    Fantastic recipes! Adore grapefruit!
    Can I use Pommelo! And a substitute for Umeboshi?
    Thank you. Thank you Thank you ♥️♥️♥️

    • Team ALG

      Yes you can use pommelo as a substitute for grapefruit. The you can use

      Yes you can use pommelo fruit as a substitute for grapefruit. You can use apple cider vinegar in place of Umeboshi vinegar.

  2. Team ALG

    Hi Marijke: We love grapefruit, too but don’t think pommelo will work as well. You can use apple cider vinegar instead of plum vinegar. Enjoy!!

  3. Diana

    Isn’t grapefruit still considered a fruit, and if so isn’t consuming it with every meal putting us over the 1 or 2 fruits per day either during the 21 day reboot or maintenance phase of the RM plan?

  4. Team ALG

    Diana, You’re having grapefruit juice in the AM, so that’s not included in the fruit serving per day and so you are just adding 1 extra serving of grapefruit per day on the RM. On maintenance you can go up to 3 servings of fruit per day. Grapefruit has so many special weight loss benefits that is a only going to help you, not hinder you in any way.


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